Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua.
Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol to bring about an abortion during pregnancy. This combination is more than 95% effective during the first 49 days of pregnancy. It is also effective in the second trimester of pregnancy. Effectiveness should be verified two weeks after use. It is taken by mouth.
Mifepristone plays a role on the receptor level of new antifertility drugs, no progesterone, androgen, estrogen activity.It has an effect on softening and dilating uterine neck. It is a new anti -progesterone, and anti-glucocorticoid activity, without progesterone, estrogen, androgen and estrogen activity. And progesterone receptor affinity is 5 times stronger than progesterone. For termination of early pregnancy, reinstating menstruation and terminating pregnancy, fetal death, etc. in induction of labor.
Mifepristone action principle that by blocking the progesterone receptor and the production of anti-pregnancy role, the effects and has been widely used clinically. Mifepristone and prostaglandin drugs used, can be used to terminate an early pregnancy amenorrhea within 49d.
Usage of a total of 150mg of mifepristone Dayton clothing or in divided doses, the first paragraph 4d 3d or oral misoprostol 600ug, abortion drug application, greatly reducing the complications caused by abortions, reducing the majority suffering women of childbearing age.
Mifepristone comes as a tablet to take by mouth. You will take one tablet of mifepristone once on the first day. Within 24 to 48 hours after taking mifepristone, you will apply four tablets in total of another medication called misoprostol buccally (between the gum and cheek) by placing two tablets in each cheek pouch for 30 minutes, then swallowing the remaining content with water or another liquid. Make sure that you are in an appropriate location when you take misoprostol because vaginal bleeding, cramps, nausea, and diarrhea usually begins within 2 to 24 hours after taking it but could begin within 2 hours. Vaginal bleeding or spotting usually lasts for 9 to 16 days but can last for 30 days or longer. You must go back to your doctor for an exam or ultrasound 7 to 14 days after taking mifepristone to confirm that the pregnancy has ended and to check the amount of bleeding. Take mifepristone exactly as directed.